IFN-λ: A New Class of Interferon with Distinct Functions-Implications for Hepatitis C Virus Research
نویسندگان
چکیده
منابع مشابه
IFN-λ: A New Class of Interferon with Distinct Functions-Implications for Hepatitis C Virus Research
Pegylated interferon-α and ribavirin (PEG-IFN/RBV) is widely used to treat chronic hepatitis C virus infection with notorious adverse reactions since the broad expression of IFN-α receptors on all nucleated cells. Accordingly, a Type III IFN with restricted receptors distribution is much safer as an alternative for HCV therapy. In addition, single nucleotide polymorphisms (SNPs) near the human ...
متن کاملSevere muscle weakness during treatment with pegylated interferon alfa for chronic hepatitis C virus infection A rare complication
Background: Interferons (IFNs) are common therapeutics for several diseases such as viral hepatitis, multiple sclerosis and malignancy. A variety of autoimmune related side effects have been observed during IFN therapy. Rare cases of myopathy, polymyositis or dermatomyositis have been reported during therapy with high doses of IFN^5. Case Presentation: In this report, we describe a case with se...
متن کاملNew inequalities for a class of differentiable functions
In this paper, we use the Riemann-Liouville fractionalintegrals to establish some new integral inequalities related toChebyshev's functional in the case of two differentiable functions.
متن کاملSTAT1 is essential for the inhibition of hepatitis C virus replication by interferon-λ but not by interferon-α
Interferon-α (IFN-α) and IFN-λ are structurally distinct cytokines that bind to different receptors, but induce expression of similar sets of genes through Janus kinase (JAK)-signal transducers and activators of transcription (STAT) pathways. The difference between IFN-α and IFN-λ signaling remains poorly understood. Here, using the CRISPR/Cas9 system, we examine the role of STAT1 and STAT2 in ...
متن کاملthe ifn-λ genetic polymorphism association with the viral clearance induced by hepatitis c virus treatment in pakistani patients
background polymorphisms in the interferon λ (inf λ) genes on chromosome 19 have been associated with clearance of hepatitis c virus (hcv) induced by interferon and ribavirin therapy however there is no such data available for pakistani patients with hcv infection. objectives in this study, the effects of single nucleotide polymorphisms (snps) have been investigated in response to treatment wit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Gastroenterology Research and Practice
سال: 2015
ISSN: 1687-6121,1687-630X
DOI: 10.1155/2015/796461